DisGeNET - a database of gene-disease associations

Source: GWASDB

Disease: Low density lipoprotein cholesterol measurement ×

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	255738
Gene Symbol:	PCSK9

PCSK9

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

18193044

2008

Entrez Id:	3949
Gene Symbol:	LDLR

LDLR

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

18193044

2008

Entrez Id:	3156
Gene Symbol:	HMGCR

HMGCR

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

18193044

2008

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

18193044

2008

Entrez Id:	9415
Gene Symbol:	FADS2

FADS2

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses.

21977987

2011

Entrez Id:	3949
Gene Symbol:	LDLR

LDLR

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses.

21977987

2011

Entrez Id:	1302
Gene Symbol:	COL11A2

COL11A2

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

18193043

2008

Entrez Id:	3949
Gene Symbol:	LDLR

LDLR

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

18193043

2008

Entrez Id:	3383
Gene Symbol:	ICAM1

ICAM1

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	3156
Gene Symbol:	HMGCR

HMGCR

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	346
Gene Symbol:	APOC4

APOC4

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	3949
Gene Symbol:	LDLR

LDLR

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	1952
Gene Symbol:	CELSR2

CELSR2

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	10087
Gene Symbol:	CERT1

CERT1

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	54957
Gene Symbol:	TXNL4B

TXNL4B

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	100533990
Gene Symbol:	APOC4-APOC2

APOC4-APOC2

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	3250
Gene Symbol:	HPR

HPR

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	255738
Gene Symbol:	PCSK9

PCSK9

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	341
Gene Symbol:	APOC1

APOC1

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	4018
Gene Symbol:	LPA

LPA

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	338
Gene Symbol:	APOB

APOB

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	64241
Gene Symbol:	ABCG8

ABCG8

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	348
Gene Symbol:	APOE

APOE

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project.

22629316

2012

Entrez Id:	64240
Gene Symbol:	ABCG5

ABCG5

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.

19060911

2009

Entrez Id:	9415
Gene Symbol:	FADS2

FADS2

CUI:	C0202117
Disease:	Low density lipoprotein cholesterol measurement

Low density lipoprotein cholesterol measurement

0.100

GeneticVariation

GWASDB

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.

19060911

2009